Anastrozole prevents the conversion of adrenal androgens (e.g. testosterone) to estrogen in peripheral and tumour tissues. As the growth of many breast cancers is stimulated and/or maintained by the presence of estrogen, anastrozole helps to treat these cancers by decreasing the levels of circulating estrogens. Anastrozole has a relatively long duration of action allowing for once daily dosing – serum estradiol is reduced by approximately 70% within 24 hours of beginning therapy with 1mg once daily, and levels remain suppressed for up to 6 days following cessation of therapy.
The incidence of ischemic cardiovascular events was increased during anastrozole therapy and patients with pre-existing ischemic heart disease should consider the risks and benefits of anastrozole before beginning therapy. Anastrozole has also been reported to decrease spine and hip bone mineral density (BMD), so consideration should be given to monitoring of BMD in patients receiving long-term therapy.
Anastrazole exerts its anti-estrogenic effects via selective and competitive inhibition of the aromatase enzyme found predominantly in the adrenal glands, liver, and fatty tissues. Many breast cancers are hormone receptor-positive, meaning their growth is stimulated and/or maintained by the presence of hormones such as estrogen or progesterone. In postmenopausal women, estrogen is primarily derived from the conversion of adrenally-produced androgens into estrogens by the aromatase enzyme – by competitively inhibiting the biosynthesis of estrogen at these enzymes, anastrozole effectively suppresses circulating estrogen levels and, subsequently, the growth of hormone receptor-positive tumours.
There is limited evidence for anastrozole’s effectiveness in men.
In one small study, anastrozole increased testosterone in older men with mild hypogonadism (low T) (Leder, 2004). In another study looking at men with low testosterone and infertility, taking anastrozole led to increased testosterone and increased sperm count in some (Shoshany, 2017).
Although anastrozole may increase testosterone levels, a recent analysis suggests that it doesn’t lead to improvements in sexual function like better erections or higher libido (sex drive). It also doesn’t improve semen quality. Currently, there isn’t sufficient evidence to recommend anastrozole as a routine treatment for low T in clinical practice (Awouter, 2020).
When compared to clomiphene, another off-label treatment for low T, men had significantly higher increases in testosterone than on anastrozole (Helo, 2015).
In some cases, a healthcare professional might consider prescribing low-dose anastrozole for men who receive TRT. The reason is that testosterone injections can increase estrogen levels, sometimes leading to unwanted breast growth (gynecomastia) in men. Arimidex and other aromatase inhibitors may reduce estrogen hormone levels in men and potentially treat gynecomastia (Rhoden, 2004).
Anastrozole is an aromatase inhibitor (AI). In simple terms, it delays the body’s natural production of an enzyme called aromatase, which is responsible for converting testosterone to estradiol.
The drug is used on a course with aromatizing anabolic steroids to reduce the negative effects of estrogen on the body. Initially, it is worth considering the positive and negative effects of estrogen on the male body.
Estrogens play an important role in various functions of the male and female body. The general health of the athlete and its results depend on these very functions.
With the help of aromatase inhibitors, the level of estrogens is controlled, the growth of which must be restrained in case of excess production. Anastrozole UK Best Price. The competent use of anastrozole allows not only to counteract aromatization, but also to simultaneously enhance the growth of free testosterone.
If you follow the dosage regimen, the agent will be perfectly tolerated by the body, without any negative consequences. For example, consider Anastrozole. The drug was invented at the end of the last century, its original purpose – the treatment of breast cancer in an operable form. The effectiveness of the drug in this area has been proven, this contributed to its popularity in sports when using anabolic steroids by athletes.
The effect of anastrozole Anastrozole in bodybuilding is used when the athlete begins to use anabolic steroids, which tend to aromatize, such as testosterone and danabol. In addition to helping with muscle growth, they can have side effects. Often men have to deal with such a problem as gynecomastia.
In simple terms, this is the growth of the mammary gland. This is due to the fact that the adrenal glands begin to produce aromatase, which converts testosterone to estrogen. That is why many athletes take anastrozole on the course of anabolic steroids. It suppresses the action of the enzyme, interfering with the destruction of testosterone and the production of estrogen.
Bodybuilders who take anabolic steroids to try to increase muscle mass and improve athletic performance can experience a range of symptoms. In some cases, males might start to grow breasts due to an increase in estrogen levels.
Arimidex lowers estrogen levels and can prevent breast growth in males. However, the drug also has side effects of its own.
In this article, we discuss what Arimidex does, why bodybuilders might use it, and the possible side effects.
How It May Work For Bodybuilding
Share on PintestArimidex may cause side effects such as joint pain, nausea, and hot flashes.
Arimidex is the brand name for anastrozole. Doctors may prescribe Trusted Sourcethe drug to postmenopausal women with certain types of breast cancer.
Arimidex stops aromatase from working in the body. Aromatase is an enzyme that makes estrogen from steroid hormones, including testosterone. By doing this, it lowers the amount of estrogen in the body.
People who use anabolic steroids for bodybuilding can experience a range of side effectsTrusted Source.
These drugs disrupt hormone production in the body and may increase estrogen. Higher levels of estrogen can cause males to develop gynecomastia, which is the enlargement of the breast glands.
By reducing estrogen levels, Arimidex could prevent gynecomastia in males taking anabolic steroids.
Arimidex can cause several side effects by disrupting hormone production in the body. For example, lower estrogen levels can lead to the thinning and weakening of bones.
Some other common side effects includeTrusted Source:
- joint pain
- nausea and vomiting
- hot flashes
It is possible to have an allergic reactionTrusted Source to Arimidex, which can cause:
- swelling around the body
- chest pain
- blurred vision
- rapid heart rate
- breast pain
The primary use of Arimidex is to treat breast cancer. It may be part of treatment for postmenopausal women with:
- Early hormone receptor-positive (HR+) breast cancer. Arimidex can lower the risk of cancer returning or spreading following surgery.
- Advanced or metastatic HR+ or HR-unknown breast cancer. It is not usually possible to treat these cancers using surgery, so doctors may prescribe Arimidex as a first-line treatment.
- Advanced or metastatic breast cancer that returns following initial treatment with tamoxifen (Nolvadex). Arimidex is a second-line treatment in these cases.
Sometimes, treatments for other types of cancer, such as ovarian cancer, might include Arimidex. However, the FDA only recommend its use for breast cancer.
Several other drugs — typically, those for the treatment of breast cancer — lower estrogen levels in the body.
For example, other aromatase inhibitors, such as exemestane (Aromasin), and a class of drugs called selective estrogen receptor modulators (SERMs) that act on estrogen receptors. Doctors may use SERMs to treat breast cancer, female infertility, and dyspareunia.
Although these drugs may lower estrogen levels, the FDA do not recommend that people take them for bodybuilding purposes.
Several natural products may also play a role in lowering estrogen levels, although there is limited scientific evidence to confirm their effectiveness. These include:
- wild nettle root
- grape seed extract